Treat and clear acne with PanOxyl Adapalene 0.1% Leave-On Gel. Adapalene USP was the first FDA-approved over-the-counter topical retinoid or acne treatment. This powerful acne treatment gel was previously available only by prescription. Now, the dermatologist developed and tested formula is available over the counter in an easy, once-daily leave-on treatment. The formula is Oil Free and Fragrance Free, and it won’t irritate skin with harsh fragrances. PanOxyl is the acne authority. Your acne is our priority. PanOxyl’s skin care is engineered to help you manage your acne. For more than 45 years, dermatologists have recommended PanOxyl. Why? Because it works. PanOxyl products help your skin look its best so you can be your clearest, most confident you.